Proto-Oncogene Vav (VAV1) Antibody

The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication.

Target	Proto-Oncogene Vav (VAV1)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA, WB, FCM
Host	Mouse
Recommended dilutions	ELISA: 1/10000, WB: 1/250, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Purified recombinant fragment of human VAV1 (AA: 121-324) expressed in E. coli.
Isotype	IgG1
Form	Liquid
Purification	Purified from ascites by Protein G chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P15498 (UniProt, ExPASy)
UniProt Secondary AC	B4DVK9, M0QXX6, Q15860
UniProt Entry Name	VAV_HUMAN
Gene Symbol	VAV1
GeneID	7409
OMIM	164875
HGNC	12657
KEGG	hsa:7409
Ensembl	ENSG00000141968
String	9606.ENSP00000472929
Molecular Weight	98.3 kDa
Buffer	PBS, containing 0.05% sodium azide.
Concentration	1 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Proto-Oncogene Vav (VAV1)

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