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VAV1 (pY174) Antibody

Catalogue No: abx000232
Price: £220.00
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VAV1 (pY174) Antibody is a Rabbit Polyclonal antibody against VAV1 (pY174). This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Target VAV1 (pY174)
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Tested Applications WB
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Synthetic Peptide. A phospho specific peptide corresponding to residues surrounding Y174 of human VAV1.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P15498 (UniProt, ExPASy)
UniProt Secondary AC B4DVK9, M0QXX6, Q15860
UniProt Entry Name VAV_HUMAN
Gene Symbol VAV1
GeneID 7409
KEGG hsa:740
String 9606.ENSP00000472929
Molecular Weight Calculated MW: 94 kDa, 98 kDa
Observed MW: 98 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on VAV1 (pY174) Antibody

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