VAV1 (pY174) Antibody

Catalogue No: abx000232
Price: £220.00
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VAV1 (pY174) Antibody

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VAV1 (pY174) Antibody is a Rabbit Polyclonal antibody against VAV1 (pY174). This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Target VAV1 (pY174)
Reactivity Human, Mouse, Rat
Origin Human
Host Rabbit
Clonality Polyclonal
Tested Applications WB
Recommended dilutions WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Immunogen Synthetic Peptide. A phospho specific peptide corresponding to residues surrounding Y174 of human VAV1.
Purification Affinity purified.
Isotype IgG
Conjugation Unconjugated
Storage Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles.
Molecular Weight 95 kDa
Swiss Prot P15498
GeneID 7409
Gene Symbol VAV1
Concentration > 1 mg/ml
Buffer PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Availability Shipped within 5-10 working days.
Note This product is for research use only.

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