Voltage-Dependent Anion-Selective Channel Protein 1 (VDAC1) Antibody

VDAC1 forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. The protein may participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.

Target	Voltage-Dependent Anion-Selective Channel Protein 1 (VDAC1)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC, FCM
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/50 - 1/100, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 95-124 amino acids from the Central region of human VDAC1.
Isotype	IgG
Form	Liquid
Purification	Purified Rabbit Polyclonal Antibody.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P21796 (UniProt, ExPASy)
UniProt Secondary AC	B3KVK4, D3DQ93, Q5FVE7, Q9UIQ5, Q9UPL0
UniProt Entry Name	VDAC1_HUMAN
KEGG	hsa:7416
String	9606.ENSP00000265333
Molecular Weight	Calculated MW: 30.8 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse, Rat, Cow and Rabbit VDAC1.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Voltage-Dependent Anion-Selective Channel Protein 1 (VDAC1)

Write a review

Your Name

Your Email Address

PMID

DOI

Your Review

Rating

Continue