Serine/threonine-Protein Kinase VRK1 (VRK1) Antibody

Serine/threonine kinase involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation. Acts by mediating phosphorylation of downstream target protein. Phosphorylates 'Thr-18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. Phosphorylates casein and histone H3. Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm. This antibody is supplied as crude ascites.

Target	Serine/threonine-Protein Kinase VRK1 (VRK1)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Mouse
Recommended dilutions	WB: 1/5000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Purified His-tagged Human VRK1 protein
Isotype	IgG1
Form	Liquid
Purification	Unpurified crude ascites.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q99986 (UniProt, ExPASy)
UniProt Secondary AC	Q3SYL2
UniProt Entry Name	VRK1_HUMAN
NCBI Accession	NP_003375.1
KEGG	hsa:7443
String	9606.ENSP00000216639
Molecular Weight	Calculated MW: 45.5 kDa
Buffer	Ascites containing 0.09% sodium azide.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Serine/threonine-Protein Kinase VRK1 (VRK1)

Write a review

Your Name

Your Email Address

PMID

DOI

Your Review

Rating

Continue