WD Repeat-Containing Protein 5 (WDR5) Antibody
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Catalogue No: abx012356
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US$427.75
(Size: 100 µl)
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Datasheet SDS
WD-repeat protein 5 (WDR5, also designated BMP-2-induced gene 3 kb or BIG-3) belongs to the family of WD-40 repeat proteins, and is essential for vertebrate development, Hox gene activation and global H3K4 trimethylation. WDR5 is a conserved subunit of Trithorax (TRX) histone methyltransferase complexes that selectively binds to dimethylated Lys4 (K4me2) in Histone H3 to promote K4 trimethylation by TRX. It is expressed in osteoblasts, chondrocytes, osteocytes and marrow stromal cells. The WDR5 protein contains 7 WD-repeats, which may play a role in its function of accelerating osteoblast differentiation.
Research Articles on WD Repeat-Containing Protein 5 (WDR5)
| Target | WD Repeat-Containing Protein 5 (WDR5) |
| Clonality | Monoclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB |
| Host | Mouse |
| Recommended dilutions | ELISA: 1/10000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Purified recombinant fragment of human WDR5 expressed in E. coli. |
| Isotype | IgG2b |
| Form | Liquid |
| Purification | Unpurified ascites. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P61964 (UniProt, ExPASy) |
| UniProt Secondary AC | Q91VA5, Q9NWX7, Q9UGP9 |
| UniProt Entry Name | WDR5_HUMAN |
| Gene Symbol | WDR5 |
| GeneID | 11091 |
| OMIM | 609012 |
| HGNC | 12757 |
| KEGG | hsa:11091 |
| Ensembl | ENSG00000196363 |
| String | 9606.ENSP00000351446 |
| Molecular Weight | 36.6 kDa |
| Buffer | Ascitic fluid containing 0.03% sodium azide. |
| Concentration | Not determined. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |