WNT1 Inducible Signaling Pathway Protein 1 / WISP1 (CCN4) Antibody

Catalogue No: abx002388
Price: £120.00
(Size: 20 µl)
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WNT1 Inducible Signaling Pathway Protein 1 / WISP1 (CCN4) Antibody

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WISP1 Antibody is a Rabbit Polyclonal antibody against WISP1. This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. It is 83% identical to the mouse protein at the amino acid level. Multiple alternatively spliced transcript variants have been identified.

Target WNT1 Inducible Signaling Pathway Protein 1 / WISP1 (CCN4)
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Tested Applications WB
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant protein of human WISP1.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC O95388 (UniProt, ExPASy)
UniProt Secondary AC A8KAG6, E7EMM5, Q5JBS6, Q5JBS7, Q5JBS8, Q9HCS3
UniProt Entry Name WISP1_HUMAN
Gene Symbol WISP1
GeneID 8840
KEGG hsa:8840
String 9606.ENSP00000250160
Molecular Weight Calculated MW: 13 kDa, 16 kDa, 21 kDa, 30 kDa, 40 kDa
Observed MW: 45 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on WNT1 Inducible Signaling Pathway Protein 1 / WISP1 (CCN4) Antibody

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