Wolf-Hirschhorn Syndrome Candidate 2 Protein (WHSC2) Antibody

This gene is expressed ubiquitously with higher levels in fetal than in adult tissues.It encodes a protein sharing 93% sequence identity with the mouse protein.Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4.This gene is mapped to the 165 kb WHS critical region, and may play a role in the phenotype of the WHS or Pitt-Rogers-Danks syndrome.The encoded protein is found to be capable of reacting with HLA-A2-restricted and tumor-specific cytotoxic T lymphocytes, suggesting a target for use in specific immunotherapy for a large number of cancer patients.This protein has also been shown to be a member of the NELF (negative elongation factor) protein complex that participates in the regulation of RNA polymerase II transcription elongation.

Target	Wolf-Hirschhorn Syndrome Candidate 2 Protein (WHSC2)
Clonality	Monoclonal
Reactivity	Human, Rat
Tested Applications	ELISA, WB, IHC, IF/ICC, FCM
Host	Mouse
Recommended dilutions	ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, IF/ICC: 1/200 - 1/1000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Purified recombinant fragment of human WHSC2 (AA: 280-511) expressed in E. coli.
Isotype	IgG2b
Form	Liquid
Purification	Purified from ascites by Protein G chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
GeneID	7469
Molecular Weight	57.3 kDa
Buffer	PBS, containing 0.05% sodium azide.
Concentration	1 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Wolf-Hirschhorn Syndrome Candidate 2 Protein (WHSC2)

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