Bifunctional 3'-5' Exonuclease/ATP-Dependent Helicase WRN (WRN) Antibody
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Catalogue No: abx026592
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US$326.25
(Size: 80 µl)
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Datasheet SDS
This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3' to 5' DNA helicase activity, and is also a 3' to 5' exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by premature aging.
Research Articles on Bifunctional 3'-5' Exonuclease/ATP-Dependent Helicase WRN (WRN)
| Target | Bifunctional 3'-5' Exonuclease/ATP-Dependent Helicase WRN (WRN) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC, FCM |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/100, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 787-816 amino acids from the Central region of human WRN. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at 2-8°C for up to 2 weeks, or at -20°C for long term storage. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | Q14191 (UniProt, ExPASy) |
| UniProt Secondary AC | A1KYY9 |
| UniProt Entry Name | WRN_HUMAN |
| Gene Symbol | WRN |
| GeneID | 7486 |
| OMIM | 114500 |
| HGNC | 12791 |
| KEGG | hsa:7486 |
| Ensembl | ENSG00000165392 |
| String | 9606.ENSP00000298139 |
| Molecular Weight | Calculated MW: 162 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |