Wilms Tumor 1 (WT1) Antibody

Catalogue No: abx001111
Price: £120.00
(Size: 20 µl)
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WT1 Antibody is a Rabbit Polyclonal antibody against WT1. This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilm's tumors. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation site upstream of and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated. [provided by RefSeq, Oct 2010].

Target Wilms Tumor 1 (WT1)
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Tested Applications WB
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant protein of human WT1.
Isotype IgG
Form Liquid
Purification Purified by affinity chromatography.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P19544 (UniProt, ExPASy)
UniProt Entry Name WT1_HUMAN
Gene Symbol WT1
GeneID 7490
KEGG hsa:7490
String 9606.ENSP00000331327
Molecular Weight Calculated MW: 33 kDa, 34 kDa, 47 kDa, 48 kDa, 49 kDa, 55 kDa, 56 kDa
Observed MW: 49 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 0.5 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Wilms Tumor 1 (WT1)

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