X-Ray Repair Cross Complementing 6 (XRCC6) Antibody

XRCC6 Antibody is a Rabbit Polyclonal antibody against XRCC6. X-ray repair cross-complementing protein 6 (XRCC6) gene encodes subunit p70 of the p70/p80 autoantigen which has a role in DNA repair or transposition. DNA helicase II complex binds preferentially to fork-like ends of double-standed DNA in a cell cycle-dependent manner, which may be mediated by XRCC6. XRCC6/5 can form a heterdimer, which function as a regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA, and also it can stablize broken DNA ends and bringing them together. Otherwise, XRCC5/6 heterdimer together with APEX1 can negatively regulate of transcription.

Target	X-Ray Repair Cross Complementing 6 (XRCC6)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB, IHC, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000, IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	A synthetic peptide corresponding to a sequence within amino acids 408-609 of human Ku70.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P12956 (UniProt, ExPASy)
UniProt Secondary AC	B1AHC8, Q6FG89, Q9UCQ2, Q9UCQ3
UniProt Entry Name	XRCC6_HUMAN
Gene Symbol	XRCC6
GeneID	2547
NCBI Accession	NP_001460.1
KEGG	hsa:2547
String	9606.ENSP00000352257
Molecular Weight	Calculated MW: 70 kDa Observed MW: 70 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on X-Ray Repair Cross Complementing 6 (XRCC6)

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