Tyrosine-tRNA Ligase, Cytoplasmic (YARS1) Antibody

YARS1 Antibody is a Rabbit Polyclonal antibody against YARS1. Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Tyrosyl-tRNA synthetase belongs to the class I tRNA synthetase family. Cytokine activities have also been observed for the human tyrosyl-tRNA synthetase, after it is split into two parts, an N-terminal fragment that harbors the catalytic site and a C-terminal fragment found only in the mammalian enzyme. The N-terminal fragment is an interleukin-8-like cytokine, whereas the released C-terminal fragment is an EMAP II-like cytokine.

Target	Tyrosine-tRNA Ligase, Cytoplasmic (YARS1)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB, IP
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000, IP: 0.5-4 µg/200-400 µg whole cell extracts. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human YARS.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P54577 (UniProt, ExPASy)
UniProt Secondary AC	B3KWK4, D3DPQ4, O43276, Q53EN1
UniProt Entry Name	SYYC_HUMAN
Gene Symbol	YARS1
GeneID	8565
OMIM	603623
NCBI Accession	NP_003671.1
HGNC	12840
KEGG	hsa:8565
String	9606.ENSP00000362576
Molecular Weight	Calculated MW: 59 kDa Observed MW: 59 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Tyrosine-tRNA Ligase, Cytoplasmic (YARS1)

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