YM-01

YM-01 is a small molecule. YM-01 is an allosteric Hsp70 inhibitor. It binds with in Hsp70's nucleotide binding domain, adjacent to ATP/ADP binding pocket. It inhibits J-stimulated ATP turnover rate. It blocks Hsc70-bag1 interaction both in vitro and in vivo and enhances binding of Hsp70 to misfolded proteins. It reduces tau levels in tau-overexpressed HeLa cells, endogenous tau in neuroblastoma cells, and endogenous tau in primary neuron from rTg4510 mice, with EC50's of low micromolar. It recovers long-term potentiation deficits in brain slices from rTg4510 mice. It also has anti-cancer activity, with an EC50 value of low micromolar against several cancer cell lines. It destabilizes oncoproteins in cells, including Akt and Raf-1. Looking for more information on HSP70? Visit our new HSP70 Scientific Resource Guide at http://www.HSP70.com.

Target	YM-01
Origin	Synthetic
Form	Solid
Purity	> 98% (HPLC)
Storage	Store at -20°C. Avoid repeated freeze/thaw cycles.
Shelf Life	12 months.
Molecular Weight	417.97 g/mol
Molecular Formula	C20H20ClN3OS2
CAS Number	409086-68-6
SMILES	[Cl-].C[n+]4ccccc4\C=C3/S/C(=C2/Sc1ccccc1N2C)C(=O)N3CC
Availability	Shipped within 5-12 working days.
Note	THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.

Research Articles on YM-01

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