YM-08

YM-08 is a small molecule. YM-08 is a Heat Shock Protein 70 (Hsp70) inhibitor that is blood-brain barrier permeable. YM-08 is a neutral derivative of the Hsp70 inhibitor MKT-077. MKT-077 reduces tau levels in cellular models, but it doesn′t penetrate the blood brain barrier. Although YM-08 was somewhat less effective than MKT-077 in anti-tau and anticancer assays, it selectively reduced pathogenic tau in brain slices, which MKT-077 did not. Furthermore,YM-08 was not retained in the kidney leading one to speculate that it would not have the nephrotoxicity that was a problem for MKT-077 in clinical trials. Looking for more information on HSP70? Visit our new HSP70 Scientific Resource Guide at http://www.HSP70.com.

Target	YM-08
Origin	Synthetic
Form	Solid
Purity	> 99% (HPLC)
Storage	Store at -20 °C.
Molecular Weight	367.49 g/mol
Molecular Formula	C19H17N3OS2
SMILES	O=C2C(\S\C(=C\c1ncccc1)N2CC)=C3\Sc4ccccc4N3C
Availability	Shipped within 5-12 working days.
Note	This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.

Research Articles on YM-08

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