YM-08
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Catalogue No: abx076595
Price:
US$507.50
(Size: 10 mg)
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Datasheet SDS
YM-08 is a small molecule. YM-08 is a Heat Shock Protein 70 (Hsp70) inhibitor that is blood-brain barrier permeable. YM-08 is a neutral derivative of the Hsp70 inhibitor MKT-077. MKT-077 reduces tau levels in cellular models, but it doesn′t penetrate the blood brain barrier. Although YM-08 was somewhat less effective than MKT-077 in anti-tau and anticancer assays, it selectively reduced pathogenic tau in brain slices, which MKT-077 did not. Furthermore,YM-08 was not retained in the kidney leading one to speculate that it would not have the nephrotoxicity that was a problem for MKT-077 in clinical trials. Looking for more information on HSP70? Visit our new HSP70 Scientific Resource Guide at http://www.HSP70.com.
Research Articles on YM-08
| Target | YM-08 |
| Origin | Synthetic |
| Form | Solid |
| Purity | > 99% (HPLC) |
| Storage | Store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| Molecular Weight | 367.49 g/mol |
| Molecular Formula | C19H17N3OS2 |
| SMILES | O=C2C(\S\C(=C\c1ncccc1)N2CC)=C3\Sc4ccccc4N3C |
| Availability | Shipped within 5-12 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |