Tyrosine-Protein Kinase ZAP-70 (ZAP70) Antibody

ZAP70 (zeta-chain associated protein kinase), a 70 kDa member of the SYK tyrosine kinase family, plays a central role in lymphocyte activation and development, and is implicated in several immune disorders.ZAP70 controls TCR (T-cell antigen receptor)-linked signal transduction pathways.Its key role in thymocytes development and mature T lymphocytes activation has been illustrated by the characterization of several human immunodeficiencies presenting with mutations in the ZAP70 gene.ZAP70 is also expressed in several types of B-cell neoplasm and is easily detected by immunohistochemistry, providing a useful prognostic marker in patients with chronic lymphocytic leukaemia.

Target	Tyrosine-Protein Kinase ZAP-70 (ZAP70)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC
Host	Mouse
Recommended dilutions	ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Purified recombinant fragment of human ZAP70 expressed in E. coli.
Isotype	IgG1
Form	Liquid
Purification	Unpurified ascites.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P43403 (UniProt, ExPASy)
UniProt Secondary AC	A6NFP4, Q6PIA4, Q8IXD6, Q9UBS6
UniProt Entry Name	ZAP70_HUMAN
Gene Symbol	ZAP70
GeneID	7535
OMIM	176947
HGNC	12858
KEGG	hsa:7535
Ensembl	ENSG00000115085
String	9606.ENSP00000264972
Molecular Weight	70 kDa
Buffer	Ascitic fluid containing 0.03% sodium azide.
Concentration	Not determined.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Tyrosine-Protein Kinase ZAP-70 (ZAP70)

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