Tyrosine-Protein Kinase ZAP-70 (ZAP70) Antibody

Catalogue No: abx016023
Price: £290.00
(Size: 100 µl)

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Datasheet SDS
ZAP70 (zeta-chain associated protein kinase), a 70 kDa member of the SYK tyrosine kinase family, plays a central role in lymphocyte activation and development, and is implicated in several immune disorders.ZAP70 controls TCR (T-cell antigen receptor)-linked signal transduction pathways.Its key role in thymocytes development and mature T lymphocytes activation has been illustrated by the characterization of several human immunodeficiencies presenting with mutations in the ZAP70 gene.ZAP70 is also expressed in several types of B-cell neoplasm and is easily detected by immunohistochemistry, providing a useful prognostic marker in patients with chronic lymphocytic leukaemia.

Target ZAP70
Clonality Monoclonal
Reactivity Human
Tested Applications ELISA, WB, IHC
Host Mouse
Recommended dilutions ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Purified recombinant fragment of human ZAP70 expressed in E. coli.
Isotype IgG1
Form Liquid
Purification Unpurified ascites.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P43403 (UniProt, ExPASy)
UniProt Secondary AC A6NFP4, Q6PIA4, Q8IXD6, Q9UBS6
UniProt Entry Name ZAP70_HUMAN
Gene Symbol ZAP70
GeneID 7535
OMIM 176947
HGNC 12858
KEGG hsa:7535
Ensembl ENSG00000115085
String 9606.ENSP00000264972
Molecular Weight 70 kDa
Buffer Ascitic fluid containing 0.03% sodium azide.
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on ZAP70

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