Tyrosine-Protein Kinase ZAP-70 (ZAP70) Antibody
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Catalogue No: abx025459
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US$623.50
(Size: 100 µl)
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Datasheet SDS
This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. This antibody is supplied as crude ascites.
Research Articles on Tyrosine-Protein Kinase ZAP-70 (ZAP70)
| Target | Tyrosine-Protein Kinase ZAP-70 (ZAP70) |
| Research Area | Enzymes and Kinases |
| Clonality | Monoclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB |
| Host | Mouse |
| Recommended dilutions | WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Purified His-tagged Human ZAP70 protein (Fragment) |
| Isotype | IgG1 |
| Form | Liquid |
| Purification | Unpurified crude ascites. |
| Storage | Aliquot and store at 2-8°C for up to 2 weeks, or at -20°C for long term storage. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P43403 (UniProt, ExPASy) |
| UniProt Secondary AC | A6NFP4, Q6PIA4, Q8IXD6, Q9UBS6 |
| UniProt Entry Name | ZAP70_HUMAN |
| KEGG | hsa:7535 |
| String | 9606.ENSP00000264972 |
| Molecular Weight | Calculated MW: 69.9 kDa |
| Buffer | Ascites containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |