Tyrosine-Protein Kinase ZAP-70 (ZAP70) Antibody

This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene.

Target	Tyrosine-Protein Kinase ZAP-70 (ZAP70)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC, FCM
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/10 - 1/50, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 276-304 amino acids from the Central region of human ZAP70.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P43403 (UniProt, ExPASy)
UniProt Secondary AC	A6NFP4, Q6PIA4, Q8IXD6, Q9UBS6
UniProt Entry Name	ZAP70_HUMAN
Gene Symbol	ZAP70
NCBI Accession	NP_001070.2 NP_997402.1
KEGG	hsa:7535
String	9606.ENSP00000264972
Molecular Weight	Calculated MW: 69.9 kDa
Buffer	PBS containing 0.09% sodium azide.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Tyrosine-Protein Kinase ZAP-70 (ZAP70)

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