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Tyrosine-Protein Kinase ZAP-70 (ZAP70) Antibody
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Catalogue No: abx001807
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US$217.50
(Size: 20 µl)
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Datasheet SDS
ZAP70 Antibody is a Rabbit Polyclonal antibody against ZAP70. This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene.
Research Articles on Tyrosine-Protein Kinase ZAP-70 (ZAP70)
| Target | Tyrosine-Protein Kinase ZAP-70 (ZAP70) |
| Research Area | Enzymes and Kinases |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | ELISA, WB, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | ELISA: 1 µg/ml, WB: 1/500 - 1/1000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant protein corresponding to ZAP70. The exact sequence is proprietary. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P43403 (UniProt, ExPASy) |
| UniProt Secondary AC | A6NFP4, Q6PIA4, Q8IXD6, Q9UBS6 |
| UniProt Entry Name | ZAP70_HUMAN |
| Gene Symbol | ZAP70 |
| GeneID | 7535 |
| NCBI Accession | NP_001070.2 |
| KEGG | hsa:7535 |
| String | 9606.ENSP00000264972 |
| Molecular Weight | Calculated MW: 70 kDa Observed MW: 70 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |