ZAP70 (pY493) Antibody

Catalogue No: abx000515
Price: £230.00
(Size: 50 µl)

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Datasheet SDS
ZAP70 (pY493) Antibody is a Rabbit Polyclonal antibody against ZAP70 (pY493). This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene.

Target ZAP70 (pY493)
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Tested Applications WB, IHC, IF/ICC
Host Rabbit
Recommended dilutions WB: 1/2000 - 1/5000, IHC: 1/50 - 1/100, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Synthetic Peptide. A phospho specific peptide corresponding to residues surrounding Y493 of human ZAP70.
Isotype IgG
Form Liquid
Purification Purified by affinity chromatography.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P43403 (UniProt, ExPASy)
UniProt Secondary AC A6NFP4, Q6PIA4, Q8IXD6, Q9UBS6
UniProt Entry Name ZAP70_HUMAN
Gene Symbol ZAP70
GeneID 7535
KEGG hsa:7535
String 9606.ENSP00000264972
Molecular Weight Calculated MW: 35 kDa, 55 kDa, 69 kDa
Observed MW: 70 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 0.5 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on ZAP70 (pY493)

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