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ZAP70 (pY493) Antibody

Catalogue No: abx000515
Price: £220.00
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ZAP70 (pY493) Antibody

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ZAP70 (pY493) Antibody is a Rabbit Polyclonal antibody against ZAP70 (pY493). This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene.

Target ZAP70 (pY493)
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Tested Applications WB, IHC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000, IHC: 1/50 - 1/100. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Synthetic Peptide. A phospho specific peptide corresponding to residues surrounding Y493 of human ZAP70.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UNSPSC Code 12352203
UniProt Primary AC P43403
Gene Symbol ZAP70
GeneID 7535
Molecular Weight Calculated MW: 35 kDa, 55 kDa, 69 kDa
Observed MW: 70 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on ZAP70 (pY493) Antibody

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