Zona Pellucida Glycoprotein 4 (ZP4) Antibody

The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo protein composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a consensus furin cleavage site, and a C-terminal transmembrane domain protein hypothesized that furin cleavage results in release of the mature the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies. Previously, this gene has been referred to as ZP1 or ZPB and thought to have similar functions as mouse Zp1. However, a human gene with higher similarity and chromosomal synteny to mouse Zp1 has been assigned the symbol ZP1 and this gene has been assigned the symbol ZP4.

Target	Zona Pellucida Glycoprotein 4 (ZP4)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/2000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 445-474 amino acids from the C-terminal region of human ZP4.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q12836 (UniProt, ExPASy)
UniProt Secondary AC	B2RAE1
UniProt Entry Name	ZP4_HUMAN
KEGG	hsa:57829
String	9606.ENSP00000482304
Molecular Weight	Calculated MW: 59.4 kDa
Buffer	PBS containing 0.09% sodium azide.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Zona Pellucida Glycoprotein 4 (ZP4)

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