Leucine-Zipper Protein Kinase (ZPK) Antibody

ZPK is a member of serine/threonine protein kinase family. This kinase contains a leucine-zipper domain, and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation.

Target	Leucine-Zipper Protein Kinase (ZPK)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/2000, IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 828-859 amino acids from the C-terminal region of human ZPK.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q12852 (UniProt, ExPASy)
UniProt Secondary AC	B3KSS9, G3V1Y2, Q86VQ5, Q8WY25
UniProt Entry Name	M3K12_HUMAN
NCBI Accession	NP_001180440.1 NP_006292.3
KEGG	hsa:7786
String	9606.ENSP00000448689
Molecular Weight	Calculated MW: 93.2 kDa
Buffer	PBS containing 0.09% sodium azide.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Leucine-Zipper Protein Kinase (ZPK)

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