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SARS-CoV-2 S1 Protein RBD (Beta B.1.351 Variant)
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Catalogue No: abx160085
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US$3,929.50
(Size: 1 mg)
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Datasheet SDS
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2/COVID-19) Spike S1 Protein Receptor-Binding Domain (RBD) is a recombinant protein expressed in Insect cells. The SARS-CoV-2 Spike Protein (S protein) is a viral protein that allows the entry of SARS-CoV-2 into human cells. The protein forms trimers on the viral capsid and binds to human Angiotensin Converting Enzyme 2 (ACE2) located on the cell surface. The protein has a cleavage site between the S1 and S2 subunits that is targeted by the human enzyme Furin, and it may also cause the development of a syncytium (cell fusion). Antibodies to S protein can prevent viral entry as well as target the virus for further immune action. The Beta (B.1.351) variant was first identified in South Africa. It contains the K417N, E484K and N501Y mutations in the spike protein's receptor-binding domain.
Research Articles on SARS-CoV-2 S1 Protein RBD (Beta B.1.351 Variant)
| Target | SARS-CoV-2 S1 Protein RBD (Beta B.1.351 Variant) |
| Research Area | Infection Immunity |
| Target Modification | Lys417Asn, Glu484Lys, Asn501Tyr |
| Modification | Mutation |
| Origin | Virus |
| Expression | Recombinant |
| Tested Applications | ELISA, WB |
| Host | Insect |
| Recommended dilutions | Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Form | Liquid |
| Purity | ≥ 90% (SDS-PAGE) |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | At least 12 months. |
| Molecular Weight | Calculated MW: 26 kDa Observed MW (12% reducing SDS-PAGE): ~28 kDa |
| Sequence Fragment | 319-541 AA. |
| Tag | C-terminal His tag |
| Buffer | PBS, pH 7.4. Does not contain preservatives. |
| Concentration | 2.5 mg/ml |
| Availability | Shipped within 10-20 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. This product is shipped with dry ice. |
| Directions for use | Centrifuge before opening to ensure complete recovery of vial contents. |
