SARS-CoV-2 Spike Protein RBD (B.1.617 Variant)

Catalogue No: abx620009
Price: £200.00
(Size: 50 µg)
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SARS-CoV-2 Spike Protein RBD (B.1.617 Variant)

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Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2/COVID-19) Spike Protein Receptor-Binding Domain (RBD) is a recombinant protein expressed in Mammalian cells.

The SARS-CoV-2 Spike Protein (S protein) is a viral protein that allows the entry of SARS-CoV-2 into human cells. The protein forms trimers on the viral capsid and binds to human Angiotensin Converting Enzyme 2 (ACE2) located on the cell surface. The protein has a cleavage site between the Spike Protein and S2 subunits that is targeted by the human enzyme Furin, and it may also cause the development of a syncytium (cell fusion). Antibodies to S protein can prevent viral entry as well as target the virus for further immune action.

The B.1.617 variant was first identified in India. It contains the E484Q and L452R mutations and is therefore widely known as a "double mutation" variant. These mutations have been reported to increase binding to human ACE2 and reduce antibody neutralization of the virus, in comparison with other variants.

Target Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Spike Protein RBD (B.1.617 Variant)
Target Modification Glu484Gln, Leu452Arg
Modification Mutation
Origin Virus
Expression Recombinant
Host Mammalian cells
Recommended dilutions Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Form Lyophilized
Purity > 90% (SDS-PAGE)
Reconstitution Reconstitute in ddH2O to a concentration of 1 mg/ml.
Storage Store at -20°C. Avoid repeated freeze/thaw cycles.
NCBI Accession YP_009724390.1
Molecular Weight Observed MW: 35 kDa
Tag C-terminal His-tag.
Buffer Prior to lyophilization: PBS, pH 7.5.
Concentration Prior to lyophilization: 2.5 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on SARS-CoV-2 Spike Protein RBD (B.1.617 Variant)

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