Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2/COVID-19) Spike Protein Receptor-Binding Domain (RBD) is a recombinant protein expressed in Mammalian cells.

The SARS-CoV-2 Spike Protein (S protein) is a viral protein that allows the entry of SARS-CoV-2 into human cells. The protein forms trimers on the viral capsid and binds to human Angiotensin Converting Enzyme 2 (ACE2) located on the cell surface. The protein has a cleavage site between the Spike Protein and S2 subunits that is targeted by the human enzyme Furin, and it may also cause the development of a syncytium (cell fusion). Antibodies to S protein can prevent viral entry as well as target the virus for further immune action.

The L452R mutation is present in the B.1.429/B.1.427 (CAL.20C/Epsilon) variant first identified in California, USA.

Target	Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Spike Protein RBD (L452R Mutation)
Target Modification	Leu452Arg
Modification	Mutation
Origin	Virus
Expression	Recombinant
Tested Applications	SDS-PAGE
Host	Mammalian cells
Recommended dilutions	Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Form	Lyophilized
Purity	> 90% (SDS-PAGE)
Reconstitution	Reconstitute in ddH2O to a concentration of 1 mg/ml.
Storage	Store between -20 °C and -80 °C. Avoid repeated freeze/thaw cycles.
NCBI Accession	YP_009724390.1
Molecular Weight	Observed MW: 35 kDa
Tag	C-terminal His tag
Buffer	Prior to lyophilization: PBS, pH 7.5.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.

Research Articles on Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Spike Protein RBD (L452R Mutation)

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